Among the enteric diseases controlled by antibiotics, avian coccidiosis and necrotic enteritis (NE) together cost the poultry industry more than $12 billion annually. Clostridium perfringens is the causative agent of NE, and coccidiosis is caused by several species of Eimeria protozoa. In this objective, we will use an “immuno-proteome approach” to prevent and mitigate coccidiosis and NE in chickens. We will also develop a “phytochemical-based strategy” to reduce NE-induced gut damage as well as optimize gut health.

As our publications related to this goal are produced, we will include them on this page.

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Use of Selected Plant Extracts in Controlling and Neutralizing Toxins and Sporozoites Associated with Necrotic Enteritis and Coccidiosis

Authors: Md Maruf Khan, Hyun S. Lillehoj, Youngsub Lee, Adedeji O. Adetunji , Paul C. Omaliko, Hye Won Kang, and Yewande O. Fasina

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Development of a new immunodiagnostic tool for poultry coccidiosis using an antigen-capture sandwich assay based on monoclonal antibodies detecting an immunodominant antigen of Eimeria

Authors: Youngsub Lee and Hyun S. Lillehoj

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Host-mediated beneficial effects of phytochemicals for prevention of avian coccidiosis

Authors: Inkyung Park, Hyoyoun Nam, Samiru S. Wickramasuriya, Youngsub Lee, Emma H. Wall, Sripathy Ravichandran, and Hyun S. Lillehoj

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Hyperimmune egg yolk antibodies developed against Clostridium perfringens antigens protect against necrotic enteritis

Authors: D. Goo, U. D. Gadde, W. K. Kim, C. G. Gay, E. W. Porta, S. W. Jones, S. Walker, and H. S. Lillehoj

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Orally delivered Bacillus subtilis expressing chicken NK-2 peptide stabilizes gut microbiota and enhances intestinal health and local immunity in coccidiosis-infected broiler chickens

Authors: Samiru S. Wickramasuriya, Inkyung Park , Youngsub Lee , Luciana M. Richer,
Chris Przybyszewski, Cyril G. Gay, Jolieke G. van Oosterwijk, and Hyun S. Lillehoj

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Bacillus subtilis Expressing Chicken NK-2 Peptide Enhances the Efficacy of EF-1α Vaccination in Eimeria maxima-Challenged Broiler Chickens

Authors: Youngsub Lee, Inkyung Park, Samiru S. Wickramasuriya, and Hyun S. Lillehoj

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Co-administration of chicken IL-7 or NK-lysin peptide 2 enhances the efficacy of Eimeria elongation factor-1α vaccination against Eimeria maxima infection in broiler chickens

Authors: Youngsub Lee, Inkyung Park, Samiru S. Wickramasuriya, Juliette Ben Arous, Mari-Eve Koziol, and Hyun S. Lillehoj

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Co-administration of chicken IL-7 or NK-lysin peptide 2 enhances the efficacy of Eimeria elongation factor-1a vaccination against Eimeria maxima infection in broiler chickens

Authors: Youngsub Lee, Inkyung Park , Samiru S. Wickramasuriya , Juliette Ben Arous, Marie-Eve Koziol, and Hyun S. Lillehoj

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Coccidiosis: Recent Progress in Host Immunity and Alternatives to Antibiotic Strategies

Authors: Youngsub Lee, Mingmin Lu, and Hyun S. Lillehoj

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Co-administration of chicken IL-7 or NK-lysin peptide 2 enhances the efficacy of Eimeria elongation factor-1a vaccination against Eimeria maxima infection in broiler chickens

Authors: Youngsub Lee, Inkyung Park , Samiru S. Wickramasuriya , Juliette Ben Arous, Marie-Eve Koziol, and Hyun S. Lillehoj

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Role of Physiology, Immunity, Microbiota, and Infectious Diseases in the Gut Health of Poultry

Authors: Samiru S. Wickramasuriva, Inkyung Park, Kyungwoo Lee, Youngsub Lee, Woo H. Kim, Hyoyoun Nam, Hyun S. Lillehoj